专家研究称:流感可能与阿尔茨海默症有联系
2025-03-12 三千流明 2644
正文翻译
近年来,关于神经退行性疾病发病机制的研究揭示了一个引人注目的方向:常见病毒感染与阿尔茨海默病、帕金森病、肌萎缩侧索硬化症等疾病之间可能存在潜在关联。传统观点认为这些疾病是年龄增长过程中不可避免的后果,但流行病学数据与生物学机制研究正在挑战这一认知。多国大规模健康数据库的长期追踪显示,经历流感、肺炎、带状疱疹等严重感染的患者,在后续数年至数十年间罹患神经退行性疾病的风险显著提升。一项覆盖30万芬兰居民的队列研究发现,因病毒性脑炎住院的患者后期阿尔茨海默病发病率激增22至30倍,类似的关联模式在跨地区验证中展现出统计学稳定性。
这种延迟性效应引发了关于病理机制的深入探讨。目前两种假说受到学界关注:其一,神经嗜性病毒可能通过直接入侵中枢神经系统触发持续炎症反应,例如单纯疱疹病毒(HSV-1)在潜伏与复发的循环中刺激β淀粉样蛋白异常沉积,这一过程在小鼠模型中已被观察到可加速神经退行进程;其二,病毒感染可能永久性改变宿主细胞的蛋白折叠系统,导致细胞器在清除病毒后仍持续错误组装内源性蛋白,形成病理性斑块。支持性证据来自HIV药物研究,某些抗病毒制剂意外展现出延缓ALS患者蛋白聚集的作用,提示病毒复制机制与神经退行过程可能存在分子层面共性。
预防医学领域为此提供了间接佐证。流感疫苗、肺炎疫苗的广泛接种不仅降低目标感染发生率,同时关联人群的神经退行性疾病发病率呈现下降趋势。这种现象可能与疫苗减轻感染严重程度有关——需要住院治疗的严重感染患者神经退行风险最高,而疫苗通过降低重症转化率间接切断这一病理链条。值得注意的是,这种保护效应具有广谱性,不同病毒疫苗对应多种神经退行疾病风险的同步下降,提示感染引发的系统性炎症或神经损伤可能是共同致病通路。
尽管因果关系的最终确立仍需长期观察,特别是新冠肺炎大流行为研究急性病毒感染与慢性神经退行过程的关系提供了自然实验场,但现有证据已足够推动公共卫生策略调整。加强呼吸道病毒、疱疹病毒等常见病原体的免疫防护,开发针对神经嗜性病毒的特异性疗法,可能成为预防神经退行性疾病的新突破口。从临床实践角度看,对严重感染患者实施长期神经功能监测,结合抗病毒药物与神经保护剂的协同干预,或将为延缓疾病进展提供新思路。随着分子检测技术的进步,未来有望通过检测特定病毒抗体滴度或神经炎症标记物,建立个体化风险评估体系,在症状出现前启动针对性预防措施。
这一研究方向的突破性在于重构了慢性病与急性感染之间的关联,将神经退行性疾病的防治窗口前移数十年。如果后续研究能确证病毒感染的核心致病作用,意味着人类可能通过完善现有疫苗体系与抗病毒治疗方案,显著降低这类毁灭性疾病的负担。尽管具体机制解析与临床转化仍需时日,但将神经退行性疾病纳入感染后并发症管理范畴,已为对抗这些曾被视为"不可避免"的老年疾病开辟了充满希望的新路径。


评论翻译
@jliller
If viral infections in adults increases chances of neurodegenerative diseases in adults what about in children?
Asking as someone who had mono in Pre-K.

如果成年人的病毒感染会增加患神经退行性疾病的风险,那儿童的情况如何?作为在学前班得过单核细胞增多症的人,我想知道这个问题的答案。

@StYxXx
Virus infections, like the flu, can cause a lot of later illnesses. Hashimoto might also get triggered by such.

病毒感染(比如流感)可能引发多种后续疾病,桥本甲状腺炎也可能因此被诱发。

@garion742
Go figure, another case of prevention is better and likely cheaper than treatment.

不出所料,这又是一个证明预防胜于治疗且成本更低的案例。

@kylenmaple4668
As someone who got COVID twice, and also got the vaccines , this is pretty sucky to hear

作为感染过两次新冠且接种过疫苗的人,听到这个消息真是糟心。
原创翻译:龙腾网 https://www.ltaaa.cn 转载请注明出处


@robindowensauthor9917
My family always believed my father got Alzheimers due to a severe bout of Scarlet fever as a child.

我家一直认为,父亲患阿尔茨海默病是因为他小时候得过严重的猩红热。

@andyt1313
Vaccines truly are one of the most beneficial inventions in human history.

疫苗确实是人类历史上最伟大的发明之一。

@HurricaneOG
So because I caught the flu at 22 I need to think about catching Alzheimers someday?

所以,就因为我22岁时得过流感,现在就得担心未来会得阿尔茨海默病?

@O-Demi
A super worrying video title for me who's caught some sort of respirotary viral infection every month since September; I'm literally sick every month.

这个视频标题让我极度焦虑——自九月起,我每月都会感染某种呼吸道病毒,字面意义上每个月都在生病。

@1dontknow4321
Viruses are lixed to many diseases. They really arent benign and should be avoided if possible. Vaccines could save you from more than the initial infection.

病毒与多种疾病相关,它们绝非无害,应尽可能避免感染。疫苗不仅能预防初次感染,还能提供更多保护。

@acaciawilliams9015
My older brother gave me cold sores as a baby. My mom kept telling him not to kiss me, but he did anyway. I'm pretty upset about it as I was a completely helpless baby who couldn't consent and now I have to live with this for the rest of my life. Stg that if I get any kind of dementia from it...

我哥哥在我婴儿时期把唇疱疹传染给了我。妈妈反复提醒他别亲我,但他还是做了。这件事让我很生气,毕竟我当时毫无反抗能力,现在却要终生承受后果。要是因此患上痴呆症,我发誓...

@sonwig5186
I luckily don't plan to live so long that I'd get Parkinson's. But also how do people even get the Flu. Like I had C*vid several times and some really bad colds but never a flu, idk how people have it every year.

幸好我不打算活到会得帕金森病的年纪。不过话说回来,人们到底是怎么得流感的?我感染过几次新冠和重感冒,但从没得过流感,实在不懂为什么有人每年都中招。

@elinope4745
Dirty teeth and strep throat cause neuro and cardiac diseases.

牙齿不洁和链球菌性咽喉炎会引发神经与心脏疾病。

@jennacarodiskeywiebe4960
Great video.
Vaccination and treatments are definitely vital- but why neglect to mention respirator masks and clean are as preventive measures? Both are easy and effective ways to lower tve risk of infection and lower viral loads.

视频很棒。疫苗接种和治疗当然重要,但为什么不提呼吸器口罩和清洁空气作为预防措施?这两者都是降低感染风险和病毒载量的简便有效方法。

@spookycreachre
Damn, great news to hear when my mom is antivax and I got the flu every single year not to mention the terrible brain fog I've got now. It feels like I'm a different person now, my capabilities are just so different.

真讽刺,我妈是反疫苗人士,而我每年都得流感,更别提现在严重的脑雾。感觉像是变了个人,能力完全不同了。

@OmegaGamer1989
Youre telling me that having a severe infection that beats the crap out of your brain could potentially lead to your brain breaking down later in life? SHOCKER. Truly, a revolutionary epiphany.
(Could you feel the sarcasm in there? Because I REALLY really meant it.)

你是说严重感染把大脑折腾得半死,可能导致晚年脑功能衰退?天呐,这真是颠覆性发现啊。(感受到我的讽刺了吗?因为我真的就是这个意思。)

@Ana2398
I wonder how many studies are/will look at these diseases conecting to Covid

不知道有多少研究正在或将会探索这些疾病与新冠的关联。

@lauravanimpe3173
Wear your respirators people! Good quality masks will save your life and brain.

大家戴好呼吸器吧!优质口罩能拯救你的生命和大脑。

@MurderMostFowl
Nice to hear some positive news in the world of public health I didnt expect to see anything for 4 years while the Secretary of Health and Human Services has the nations collective head in the sand.

听到公共卫生领域的好消息真不错。过去四年卫生与公众服务部长让全国集体逃避现实,我本不指望能看到任何进展。

@jaybanks7718
One paper I read had the theory that each flu/bad cold kills some neurons. This is okay, but with getting sick over the years, the loss of neurons adds up until it isn't okay (heavily paraphrased). Regardless, you could say that it is a lack of fitness, because fit people get sick less. See: "A 2024 study found that people who exercise regularly are much less likely to get COVID-19 or be hospitalized with it, compared with people who don't exercise regularly." The new hotness is Alzheimer's is a vascular disease. So, virus or fitness, either way exercise is the solution.

我读过一篇论文提出理论:每次流感/重感冒会杀死部分神经元。这暂时没问题,但多年累积的神经元损失终将引发问题(大意如此)。不管怎样,可以说这是缺乏锻炼的结果,因为健康人群患病更少。参考:"2024年研究发现,定期锻炼者感染新冠或住院的概率远低于不锻炼者"。最新观点认为阿尔茨海默病是血管疾病。所以无论病毒还是体质,锻炼都是解决之道。

@Fofut
Flu injections don't stop the infection only lessons the symptoms & duration so the working don't take as much time off. To some it doesn't affect the virus at all. Specifically where the autoimmune system attacks everything, good or bad.

流感疫苗不能阻止感染,只能减轻症状和缩短病程,让打工人少请病假。对某些人(尤其是免疫系统无差别攻击的人群)来说,疫苗对病毒完全无效。
原创翻译:龙腾网 https://www.ltaaa.cn 转载请注明出处


@nancienordwick4169
The fact that spike protein can lead to rapid onset vascular dementia was very helpful to eliciting this!

刺突蛋白可能导致快速发作的血管性痴呆,这一事实对引发此研究非常关键!
原创翻译:龙腾网 https://www.ltaaa.cn 转载请注明出处


@bonniesmith7277
It would be great to include non pharmaceutical interventions as prevention as well! Respirators, air purifiers, and paid sick leave all make meaningful differences in breaking chains of transmission.

若能纳入非药物干预作为预防措施就更好了!呼吸器、空气净化器和带薪病假都能有效阻断传播链。

@Jacob-bm6wb
I dont get the flu, covid, or mono since I wear n95 masks. I dont get herpes for another reason

自从戴N95口罩后,我没得过流感、新冠或单核细胞增多症。至于疱疹...没得是另有原因。

@Jacob-bm6wb
Studies and people have been yelling about it since like the first year of covid. Luckily masks are effective against all of them especially the flu

从新冠爆发第一年起,研究和民众就在呼吁这事。幸好口罩对所有病毒都有效,尤其是流感。

@diyeana
My grandparents both had dementia, got their flu shots every year, and were never sick. Viruses like the flu, mono, and HSV-1 are so common, how can you reliably make a connection? You can find data, and anecdotes, supporting either way.

我祖父母都患痴呆症,每年接种流感疫苗且从不生病。流感、单核细胞增多症和HSV-1病毒如此普遍,如何建立可靠关联?正反两面的数据和案例都能找到。
原创翻译:龙腾网 https://www.ltaaa.cn 转载请注明出处


@victoriamahon3765
Keep in mind that there are other post viral infections that can cause similar symptoms, many people that have ME/CFS developed that disease after an Epstein-Barr infection that disease causes brain fog and severe fatigue and muscle and neurological symptoms so this is not a stretch at all to patients that are familiar with me/cfs and similar conditions. Furthermore, that disease has been so grossly ignored underfunded, and un research for literally decades. How much further would we be in other medical research if somebody had paid attention to all the patients that have been begging for help its such a complex disease with so many different facets that its turning out that theres lixs and similarities to so many other major conditions. That is the only bright spot coming off of Covid is that people are finally starting to pay attention and looking at ME/CFS and long Covid research.

请记住,其他病毒感染后遗症也会引发类似症状。许多ME/CFS(肌痛性脑脊髓炎/慢性疲劳综合征)患者是在EB病毒感染后发病的,该疾病会导致脑雾、严重疲劳及肌肉神经症状。因此,对熟悉ME/CFS的患者来说,这种关联并不牵强。更何况,这种疾病数十年来一直被忽视、资金不足且缺乏研究。若当初有人关注过这些求助的患者,其他医学研究领域本可取得更大进展——该病如此复杂,涉及多个层面,现已发现与多种重大疾病存在关联。唯一的好消息是,新冠让人们终于开始重视ME/CFS和长新冠研究。

@susanb4317
I guess well have to hope some other nation finds out about this and tells us in America.

看来我们只能指望其他国家先发现真相,再来告诉美国了。

@1DangerMouse1
Too bad that in the USA they're actually talking about taking away funding for flu vaccines and a meeting was just canceled regarding the next seasonal flu vaccine

可悲的是,美国居然在讨论削减流感疫苗资金,连下季流感疫苗的会议都被取消了。

@ubertante
But arent people who are elderly now a well-vaccinated group?

但现在的老年人不正是疫苗接种率较高的群体吗?

@aallen9287
They should get a dataset from Japan. A country were vaccination and mask wearing while ill is common. I would suppose the relationship between infections and NDDs would be more obvious.

他们应该采用日本的数据集。这个国家疫苗接种率高,生病时戴口罩很普遍。我猜感染与神经退行性疾病的关系会更明显。

@kalipw0210
I cant stop relating this to prions for some reason. Its improperly folded goo lol

不知为何,我总联想到朊病毒。都是错误折叠的蛋白质糊状物啊,哈哈。

@tethergobrrr
Childfree people could be useful in trials. I get WAY fewer viruses than my siblings with kids. And my parents with grandkids. Probably a quarter of the frequency which is a lot of flus over a lifetime.

没有孩子的人可能在临床试验中很有用。与有孩子的兄弟姐妹相比,我感染病毒的频率低得多,连有孙辈的父母也是如此。我的感染率大概是他们的四分之一,这相当于一生中少得很多次流感。
原创翻译:龙腾网 https://www.ltaaa.cn 转载请注明出处


@a-goblin
shout-out to all my fellow flu sufferers!
i got the flu vaccine, still got it, but let's hope we don't get alzheimers until we're 105!

向所有和我一样被流感折磨过的战友们致敬!虽然打了疫苗还是中招了,但希望我们至少能撑到105岁再得老年痴呆吧!

@fips001
While at the same time the US government is cutting research funding ....

然而与此同时,美国政府却在削减研究经费......

@ChrisTaylor-dz6nk
I've never had the flu.im 67years old.dont know why.never had a flu prick. And no covid. Tested 5 times family positive me negative. Negative. How.

我今年67岁,从没得过流感,也不知道为什么。没打过流感疫苗,也没感染过新冠——家人阳性时我测了五次都是阴性。这到底怎么回事?

@KarenConvery-k9e
Pneumonia vaccine is protective against Streptococcus Pneumoniae, a bacteria not a virus.

肺炎疫苗针对的是肺炎链球菌,这可是细菌不是病毒,这点要澄清清楚。

@hinglemccringleberry1824
This is what ME/CFS researchers have been saying for a decade now. Glad to see it being picked up.

肌痛性脑脊髓炎/慢性疲劳综合征(ME/CFS)的研究者们十年前就在说这个了,很高兴终于有人关注到。

@sw6118
Sorry but I think whatever sets off the NDD is contagious AND the NDD and some cancers are contagious too.

虽然听起来很离谱,但我怀疑不仅是触发神经退行性疾病的因素具有传染性,连这些疾病本身和某些癌症也可能传染。

@Nova-jj6ov
Yet another reason why getting vaccinated and wearing a mask is so important!

这又给了我们一个接种疫苗和戴口罩的重要理由!
原创翻译:龙腾网 https://www.ltaaa.cn 转载请注明出处


@Steampunkkids
If only there was a way to make your doctor take your symptoms seriously before its too late :(

要是在为时已晚之前,能有办法让医生认真对待我们的症状就好了

@lnplum
Oh that's great to see pop up in my recommendations while I'm battling the worst flu I've ever had.

真棒,在我经历人生最严重流感时,这个视频出现在推荐列表里。

@AndDiracisHisProphet
i am lying on the couch with the flu....not a video i wanted to see.

此刻正因流感瘫在沙发上的我...真不想刷到这个视频。

@Debbie-henri
Ah, thanks... I thought this would be about flu (which I've only ever had a couple of times).
Instead, it's about a number of illnesses - including Shingles, which has been reinfecting me for over 40 years, and Mono, which put my son in hospital.
I wish I hadn't clicked on this now

啊,谢谢...我还以为视频主要讲流感(我只得过两三次)。结果内容涉及多种疾病——包括困扰我40多年的带状疱疹,还有让我儿子住院的传染性单核细胞增多症。现在真后悔点开这个视频。

@KenoticMuse
Highly speculative. The video presenter is correct that highly prent diseases could correlate to a lot of things, and being able to reproduce the result across different countries reduce the odds of that a bit; but they're talking about over 40 types of common viral infections, and a lot of people get these infections across all countries, so reproducing the results across countries is not enough to rule out the possibility that the correlation is spurious. This video makes it sound like we have pretty good reasons to think that viral infections cause NDD's, but it seems far from it. It doesn't help science when the media over-sell scientific results. Let science do its job.
What is a regular person supposed to do with this piece of information? Freakout a bit whenever they get hospitalized by the flu? And what would that be based on? Correlative data that's still getting vetted? I think it's fine to release news for the sake of entertainment ... but the headline for this video is saying "X could be the CAUSE for one of the most terrifying disease you'll ever face", and that seems more like a headline designed to inform and raise awareness, as if people need to take public action.
The last point I want to make is this video should be more careful about statements of "causation". What we have here is statistical correlation, and correlation is still a powerful reason to take action when there's enough scrutiny and data, but if we do not have confidence in knowing the mechanisms for causation ... then it's NOT a causal theory. It's still just correlation dressed in the word "cause", which often makes people feel more justified in their beliefs than perhaps they should be (feeling justified to take extreme actions or inaction). The word "cause" is a powerful idea, and we should not abuse it.

这个推论太牵强。视频主讲人说得对,流行疾病可能与许多事物存在相关性,跨国验证结果确实能降低偶然性,但他们讨论的是40多种常见病毒感染,且这些感染在全球范围都很普遍,因此跨国验证并不足以排除伪相关可能。视频给人"病毒感染导致神经退行性疾病"证据确凿的错觉,但事实远非如此。媒体过度炒作科学发现对科研无益,应该让科学自己说话。
普通人该如何处理这种信息?每次因流感住院就恐慌?这种恐慌的依据是什么?尚未验证的相关数据?我觉得作为娱乐新闻发布没问题...但视频标题却写着"X可能是你最恐惧疾病的元凶",这更像是为提升公众意识设计的警示性标题。
最后要指出,视频使用"因果关系"的说法不够严谨。我们目前只有统计相关性,虽然足够的数据支持下相关性可作为行动依据,但若无法明确机制,就不能称为因果理论。用"导致"包装相关性,容易让人产生错误认知(比如采取极端行动或消极应对)。"导致"这个词具有强大暗示性,不应滥用。

@maddybroedel9535
Not at all the video title I wanted to see, mindlessly scrolling through my feed in a flu-induced haze

在流感导致的昏沉中无意识刷着推荐页,这绝对是最不想看到的标题。

@himbopiss5581
Just got the flu for the first time in my life, why youtube?

人生第一次得流感,油管你为什么要这样对我?

@popcorn200213
I was JUST reading a paper about this possible lix - in relation to West Nile Virus and NDD's - and it referred back to the studies about Influenza and ESBV @.@ Then y'all post this! We are on the same brainwave!!! [And I was looking into it, after the video you guys posted about Chronic Fatigue Syndrome!]

我刚在读关于西尼罗河病毒与神经退行性疾病关联的论文,文中引用了流感和EB病毒的研究,结果你们就发了这个视频!我们脑电波同步了!!!(我还是在看了你们发布的慢性疲劳综合征视频后才开始研究的!)

@cameronbeyer7687
My grandma got the flu shot every year. The last one she got caused an auto immune reaction that left her almost entirly paralized. All she could do was moan for the next two years until she passed.
3 independent doctors verified this is what happens and my grandfather is still stuck in legal battles because the state is acting like she was in poor health prior. (Once again 3 different doctors independently verified it was the shot.)
I haven't gotten one after that and i don't plan on it. Its kinda horrifying. I think it would be an interesting video sybject in general

我奶奶每年都打流感疫苗,但最后一针引发了自身免疫反应,导致她几乎全身瘫痪。接下来的两年里她只能呻吟度日,直到去世。
三位独立医生都确认了这个诊断,但政府坚称她原本健康状况就不好,祖父至今仍在打官司(再次强调,三位不同医生独立验证是疫苗导致的)。
此后我再没打过流感疫苗,也不打算打。这件事太可怕了,感觉可以单独做期视频来讲。

@eupheme1
This is just an anecdote, of course, but my grandmother got shingles (caused by varicella zoster virus) and seemingly straight after developed Alzheimer's disease.

虽然只是个例,但我奶奶得带状疱疹(水痘-带状疱疹病毒引起)后,紧接着就患上了阿尔茨海默症。

@burnyizland
This makes so much sense! As someone on year...?17? of "living" with ME/CFS I really hope they figure this stuff out quickly. If they can save my son(whose immune system seems very similar mine) from having to go down the same path as me I'll consider that a win. Thankfully he's already got more vaccines than were available to me growing up, and he's not being put through the trauma I was, but it's those epigenetic markers that have me worried.

这完全说得通!作为与ME/CFS共处...17年?的患者,我真心希望研究能快速突破。如果能让我儿子(他的免疫系统和我很像)免于重蹈覆辙,我就心满意足了。庆幸的是他现在能接种的疫苗比我小时候多得多,也没经历我受过的创伤,但那些表观遗传标记还是让我担心。

@drzarkov39
Everybody gets the flu? Everybody gets mono? Everybody gets herpes? I've never had mono or herpes.

谁说人人都得过流感?都得过单核细胞增多症?都得过疱疹?我这儿可没得过单核细胞增多症,疱疹也没沾过边。

@Knobbler
Take it from my sister: You can't get Alzheimer's if you've got sawdust for brains.

我姐说了:只要你脑袋里装的是锯末,就不用担心得阿尔茨海默症。
原创翻译:龙腾网 https://www.ltaaa.cn 转载请注明出处


@luck484
I am buying the causal lix. There is Prion disease, which were called "slow viruses" when they were first noticed. The pathology of the diseases are characterized by a build up of plaque in the brain. If memory serves, the plaque is simply a protein string that is folded in an unusual way. The question is how and why does a malformed protein string replicate itself. Viruses hijack a particular cell's replication mechanism. Protein string don't do that.

我完全相信这种因果关系。朊病毒病刚被发现时被称为"慢病毒",其病理特征就是大脑中斑块的堆积。虽然记忆可能不准确,但斑块其实就是一种以特殊方式折叠的蛋白质链。问题在于这种错误折叠的蛋白质链如何以及为何会自我复制。病毒会劫持特定细胞的复制机制,但蛋白质链可不会这么干。

@wannacashmeoutside
Thats like saying eating breakfast MAY cause car crashes ️ (because many accidents happen in the morning, after people had breakfast)

这就好比说"吃早餐可能导致车祸"(因为很多事故都发生在人们吃完早餐的早晨)一样荒谬。

@skycloud4802
Probably used to know this, but I had an outbreak of flu last week.

这些知识我以前可能学过,但上周得了流感之后全忘光了。

@startrek2365
Honestly just reducing these deseases could be huge. I've loast a few people to them and they are such a hard way to loose someone.

说真的,只要能减少这些疾病就是重大突破。我因此失去了好几位亲友,这种失去方式实在太煎熬了。

@jasondreams202
Severe enough infections that can warrant a trip to the hospital where medications are administered. Weird that the possibility of an exposure to certain medications wasnt discussed as a possible cause

需要住院治疗的严重感染本身就涉及药物使用,奇怪的是视频居然没讨论接触某些药物作为潜在致病因素的可能性。
原创翻译:龙腾网 https://www.ltaaa.cn 转载请注明出处


@BreakChannelZero
I...uh...never had mono. But I have MS. I also don't know if I've ever gotten the flu. If so, it would have been so far back into my childhood that I have no memory of it.

我...呃...从没得过单核细胞增多症,但有多发性硬化症。至于流感,就算小时候得过也完全没印象了。

@laurakuhlmann1626
What a wonderful time to have a new head of the American HHS who is shutting down vaccine programs

美国卫生与公众服务部新部长正在关闭疫苗项目,这时间点选得可真"妙"啊。

@Holy.HannaH
Lol viruses dont "cause" them, it's a correlation because the viruses rely on our mitochondria. NDD's are caused by all the negative affects of faulty mitochondria. You're all at a much higher risk than you think.

笑死,病毒不是"导致"这些病,只是相关而已,毕竟病毒依赖我们的线粒体。神经退行性疾病其实是故障线粒体带来的各种负面影响造成的,各位的实际风险比想象中高得多。

@wormspeaker
I'm betting that we'll find a political correlation between conservative views and increased NDDs over the next few decades. They sure have taken up the mantle of vaccine rejection.

我敢打赌,未来几十年我们会发现保守派观点与神经退行性疾病增加存在政治关联。毕竟他们可是把反疫苗的大旗扛得稳稳的。

@ericaroberts3919
Please let me know if I just missed this! What if the people who are susceptible to severe infections are also just more susceptible to dementia and Alz? Eg: genetic predisposition to both conditions independently, or an autoimmune disease that could cause both more severe infection and also attack the brain.

要是我漏看了请指正!有没有可能易受严重感染的人群本身就更容易患痴呆和阿尔茨海默?比如存在独立遗传倾向,或某种既会导致严重感染又会攻击大脑的自身免疫疾病?

@H0A0B123
I bet in some years they'll discover that the flu prevents NDDs.

我赌过几年他们又会发现流感能预防神经退行性疾病。

@doris3594
I recall Dr Michael Greger stating there was a longer life connection amongst those who got flu shots. Makes sense.

我记得Michael Greger博士说过接种流感疫苗与长寿存在关联,这么看来确实合理。

@MsBELLE7
Just wait until they see what covid did to all of our brains. I have for sure had a deminished mental state since having covid the second time. My words dont come to me as they used to, and I stumble over words when speaking and listening now.

等着看新冠对我们大脑的长期影响吧。自从二次感染后,我的认知能力明显下降,现在说话找词困难,连听人讲话都会卡壳。

@StellaTheCatGirl
I now, very much regret not getting flu shots (since I am deathly afraid of needles) Then again its not like Ive actually been getting the flu, as far as I know I suppose Ill be changing that habit of not getting the shot

现在超后悔没打流感疫苗(虽然我晕针),不过话说回来,据我所知我也没怎么得过流感。看来得改改这个不打疫苗的毛病了。
原创翻译:龙腾网 https://www.ltaaa.cn 转载请注明出处


@aw8079
One must be able to afford health care before this means anything.

得先看得起病,这些研究结论才有意义啊。

@joedance14
Just thinking out loud: could severe viral infections also be related to other chronic diseases like arthritis, RA, cataracts, diabetes?

随便想想:严重病毒感染会不会也与其他慢性病有关?比如关节炎、类风湿、白内障、糖尿病?
原创翻译:龙腾网 https://www.ltaaa.cn 转载请注明出处


@fargoththemoonsugarmaniac
why is this getting shown just right now as i have the flu the first time in ages.

为啥偏偏在我多年不遇得流感的时候,给我推这个视频?

@ColCurtis
The flu isn't a stomach virus. What people call the stomach flu can be viral gastroenteritis. Influenza is a whole body illness.

流感不是肠胃病毒。人们说的"肠胃型流感"其实是病毒性肠胃炎,真正流感是全身性疾病。

@katie-kb6qd
As someone who after COVID suddenly has new chronic conditions that have greatly impacted my quality of life (my esophagus no longer contracts when I eat for example), who also JUST had the flu for the first time, I regret watching this lmfaoooo such a fascinating topic though.

作为新冠后突发多种慢性病(比如食道失去收缩功能)又刚经历人生首次流感的人,看完这个视频真是悔不当初哈哈,虽然话题确实引人入胜。

@alphafitter4699
What if it was as simple as improving your microbiome? There is plenty of research to suggest that these flu viruses interrupt the microbiome(especially Covid). So instead of getting multiple vaccinations you just focused on restoring or endlessly improving the microbiome.

要是改善肠道菌群就能解决问题呢?大量研究表明流感病毒(尤其是新冠)会破坏菌群。或许比起不停打疫苗,专注修复和优化菌群更有效?
原创翻译:龙腾网 https://www.ltaaa.cn 转载请注明出处


@karljiks
feeling really blessed right now to have a congenital heart defect which puts me on the free yearly flu shot list

突然觉得先天性心脏缺陷真是"福气"——能享受免费年度流感疫苗。

@erfilika1119
Big pharma entered your feed. You're fine, people. Watch your diet.

大药厂开始操控推送了。别慌各位,注意饮食就行。

@bath_foam4576
i know vaccines don't cause autosm, but in the wild, infinitesimally small chance than it does, i'd rather be socially awkward and hyper fixated on star trek than have alzheimer's

虽然疫苗不会导致自闭症,但就算有亿万分之一的可能,我宁愿做个沉迷《星际迷航》的社交怪人,也不想得阿尔茨海默症。

@KevinConnolly-ob9kp
Having suffered with the flu myself i was worried so i did a thousand page thesis on this very subject. I can't remember where i put it.

得过流感后太担心,于是写了千页论文研究这个课题。现在?完全记不得论文放哪了。(玩梗)
原创翻译:龙腾网 https://www.ltaaa.cn 转载请注明出处


@LuciTerra666
I understand that we do human trials before releasing it to the general public, but doesn't testing on rats not skew data between species? No medicine is a one size fits all. There's always outliers.

理解新药上市前要做人体试验,但用老鼠做实验不会导致跨物种数据偏差吗?毕竟没有万能药,总有特例存在。

@carinaekstrom1
So don't get the flu. There are better ways to avoid the flu than to get a vaccine. At least for most people.

所以别得流感就行。对多数人来说,不打疫苗也有更好的预防方式。

@therabbithat
We don't know yet if the plaques are a cause or a result of these conditions and their symptoms, unless my info is out of date? Lots of people on autopsy have a f-tonne of amaloid plaques but no symptoms of Alzheimers or anything else

斑块到底是病因还是病症表现?据我所知(可能过时了),很多尸检发现大量淀粉样斑块的人生前根本没阿尔茨海默症状。

@chimokla
how about his hypothesis for connecting those seemingly unrelated facts. What if healthy people, which take care of themselves and their body, have a tendency of having less diseases, either flu or alzheimer's. and people which doesn't take proper case of their body and health will end up with more flu throughout their life and alzheimer's?

他这个关联看似无关事实的假说如何?或许注重养生的人本就较少患病(无论是流感还是阿尔茨海默),而不重视健康的人既容易得流感,晚年也易患痴呆?

@finaltheory778
Getting neurodegenerative diseases is definitely the worst nightmare for me. If only we had effective measures to prevent infection - such as cheap and easily available masks. Oh no. (Plus, given the infection mode of SARS-CoV-2, you really also don't want LongCovid since even mild or asymptomatic infections can cause it, and even vaccination only reduces the risk but doesn't eliminate it.) Demand cleaner air.

患上神经退行性疾病绝对是我的终极噩梦。要是有便宜易得的口罩这类有效防感染措施就好了。更别提新冠病毒的传播方式——你绝对不想得长新冠,因为就算轻症或无症状感染也可能中招,疫苗也只能降低风险而非杜绝。我们需要更洁净的空气!

@goparra09
Maybe people who bother to get vaccines also take other protective health precautions like Vigorous exercise and eat healthy foods.

或许愿意接种疫苗的人本身就更注重健康防护,比如坚持锻炼和健康饮食。

@aidanteall7186
I am definitely still dealing with an amount of brain fog about a week after the flu now. Hopefully that gets better over time.

流感痊愈一周了,脑雾症状依然存在,但愿能随时间改善。
原创翻译:龙腾网 https://www.ltaaa.cn 转载请注明出处


@powdork
There is a difference between things you get vaccinated for and you're all good, and things that require the majority of the population to get vaccinated for. The video didn't go into that at all, and at this point it doesn't seem like we'll be getting herd immunity on any new diseases going forward. FML

个人接种就有效的疫苗和需要群体免疫的疫苗是两码事。视频完全没提这点,而照现在这趋势,新疾病就别指望群体免疫了。真是日了狗了。

@Zemaj
But? But? Didnt your President simply advise everyone to inject bleach?

等等?你们总统不是建议全民注射漂白剂吗?

@lwliu1112
THis is a great counter argument to those idiot anti vaxxers who think theyd rather just tough it out with viral infections

这可是打脸那些宁愿硬扛病毒感染的反疫苗蠢货的绝佳论据。

@RXP91
Problem is you need to get vaaxed every 3 months for covid. Hardly anyone is doing that. Vaccine only is a strategy but combine it with clean air, n95s and healthy life style massively reduces the risk

问题在于新冠疫苗需要每三个月接种一次,但几乎没人这么做。单靠疫苗是不够的,必须结合洁净空气、佩戴N95口罩和健康生活方式才能大幅降低风险。

@HansMilling
Herpes is not deadly, so that is why nobody ever bothered to find a vaccine or cure. That makes me angry. But perhaps it will be beneficial for society to actually work on a cure, now that there is a lix to deadly and costly diseases. I look forward to getting a cure.

疱疹本身不致命,所以没人费心研发疫苗或疗法,这让我很愤怒。不过既然现在发现它与致命且治疗费用高昂的疾病有关联,或许社会终于会重视治疗手段的研发了,我期待治愈方法问世。

@flemtone
A compromised immune system is more likely to get colds and flu's, as are people low in Vitamin D who aren't as active as they should be.

免疫系统受损的人更容易感冒和患流感,缺乏维生素D或缺乏运动的人群也是如此。

@zachrowell6795
Luckily Ive never had the flu, or mono. Covid once, and Strep Throat 5 years in a row as a child. Hopefully I dont get some crazy NDD they name Rowellism from all my Strep, wish me luck

幸运的是我从未得过流感或单核细胞增多症。成年后感染过一次新冠,但小时候连续五年患链球菌性喉炎。希望这些链球菌感染不会让我得个以我名字命名的神经退行性疾病"罗威尔症",祝我好运吧。

@aaronmacy9134
As a hypochondriac who suddonly has a bunch of actual, diagnosed issues after getting covid for the first time IN 2024.. i probably shouldnt watch this.

作为2024年首次感染新冠后突然确诊多种疾病的疑病症患者,我大概不该看这个视频。

@bromero88
Thankfully I'm an oddity and almost never get the flu. It's been over a decade since I last had it. This is the only vax I don't need to get. I seem to be resistant to some virus. Colds are very mild.. It took the beginning of last year before I got covid for the first and only time. It was no worse than a cold. BUT now I'm extremely concerned we have idiots running the show AGAIN here in the States.

庆幸的是我体质特殊,几乎从不感冒,上次得流感已是十多年前。这是我唯一不需要接种的疫苗。我对某些病毒似乎有抵抗力,即使感冒症状也很轻。直到去年初才首次感染新冠,症状和普通感冒差不多。但现在我非常担心美国又让蠢货掌权了。

@nonid7016
Flu isn't a disease! It's your body's response to a build up of toxins in your body, the flu is your bodies way of clearing out those toxins

流感不是疾病!它是身体对毒素堆积的反应,是身体自我排毒的方式。

@Corqii
as someone whose body was wrecked by the covid i caught in november of 2019, i sure hope not! i still cant breathe right and i have pots symptoms!

作为2019年11月感染新冠导致身体垮掉的人,我真心希望不是这样!至今仍有呼吸困难及体位性心动过速症状!

@b_uppy
The 1917 flu did skew the population such that those remaining were older, that may be one way to skew results.
Another way is that some people may be more susceptible flu because they lack the genes that make them safe from neurodegenerative diseases.
Could be that other health influences like food, or clean water, or even the stress from a pandemic can make survivors more susceptible to the flu...
Lots of reasons why numbers can skew in favorable/dexerious ways...

1918大流感导致人口结构老龄化,这可能影响研究结果。另一种可能是某些人因缺乏抗神经退行性病变基因而易感流感。其他因素如饮食、净水供应、疫情压力也可能提高幸存者流感易感性...数据偏差存在多种可能性。

@deniswilliam7051
I wish you had mentioned which HIV medication might treat ALS plaque. I contracted Mono because I had HIV. Because of my HIV treatment I am truly only concerned about developing MS due to contracting mono

希望你能说明哪种HIV药物可能治疗ALS斑块。我因HIV感染而患上单核细胞增多症,得益于抗HIV治疗,现在唯一担心的是单核细胞增多症引发多发性硬化症。

@waxwinged_hound
It gives me a little bit of comfort, seeing as I get my routine vaccinations each year, that my brain won't fall apart. However, I do still have symptoms of long covid, the most prominent being executive dysfunction. So uh. Jury's still out I guess.

每年定期接种疫苗让我对大脑健康稍感安心,但仍有长期新冠症状,最明显的是执行功能障碍。所以...结论尚待观察吧。

@threeMetreJim
It's a good job that COVID doesn't cause NDDs then, seeing as almost everybody on the planet has had it.

幸好新冠不会导致神经退行性疾病,毕竟全球几乎人人都感染过了。

@j.d.4697
But surely Americans are immune to Alzheimer what with their brains being mush already anyway.

美国人肯定对阿尔茨海默免疫啦,毕竟他们脑子早就成浆糊了。

@chunkycheesemonkey99
Its really too bad vaccines are scary now to the uneducated halfwits that make up majority america otherwise we might be able to fix this

可悲的是美国多数愚民现在害怕疫苗,否则我们本可能解决这个问题。
原创翻译:龙腾网 https://www.ltaaa.cn 转载请注明出处


@bjdefilippo447
I'm very confused by the introduction. While Parkinson's, Alzheimer's, and other types of dementia are, indeed, more common among the elderly, they have never been a consequence of aging. Decades of research suggests that these disorders can develop as a result of genetic predispositions, substance use/exposure, or having certain virus-triggered diseases.

开头让我很困惑。虽然帕金森、阿尔茨海默等痴呆症在老年人中更常见,但从来不是衰老的必然结果。数十年研究表明这些疾病源于遗传倾向、物质滥用/暴露或特定病毒触发。

@bomafett
If only we had a National Institute of Health that could fund research...

要是我们有个能资助研究的国家卫生研究院就好了...

@emilyk5003
That part in the beginning about people assuming neurodegenerative diseases are a part of life reminds me of type 1 diabetes. Something that is often caused by the flu, but theres a pervasive myth that people are born with it. There are some rare genetic disorders that seem to cause type 1 but not nearly as much as flu infections.

开头提到人们认为神经退行性疾病是人生必经阶段,这让我想到I型糖尿病。它常由流感引发,但普遍误传为先天疾病。虽有罕见遗传病例,但远少于流感诱发病例。

@oldcowbb
what if its the other way around, people with high risk of alzheimer are more prone to having severe flu

如果是反过来的情况呢?阿尔茨海默高风险人群可能更易患重症流感。

@troywallace7011
Since some vaccines use a live deactivated virus and some use a dead virus, could there be a lix to the vaccines also contributing to this?

既然有些疫苗使用灭活病毒,有些使用死病毒,是否疫苗本身也可能与此有关?

@anotherplottwist
My brain has Alzheimer's from that cold last year i tell ya, they tested for everything but came back negative everywhere. I just told everyone in the family it was birdflu ️. But having a temp over 101 for six weeks is BULL S️

我敢说去年那场感冒让我得了阿尔茨海默,虽然所有检测都阴性。我只好跟家人说是禽流感,但连续六周高烧41度以上真是见鬼了。

@Brian-L
Oh boy, severe case of chicken pox, the vid and two severe bouts of flu and Ive had an essential tremor as long as I can remember. Seems the writing is on my wall

天啊,我得过严重水痘、两次重症流感,从小就有原发性震颤,看来命运早已写好结局。

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